Team Leader 1:
 Ruud. H. Brakenhoff, PhD
Role: Professor of Cancer Genetics – Responsible for OraMod clinical study
Telephone: +31(0)204440953
Fax: +31(0)204443688

Team Leader 2: Mark A. van de Wiel
Role: Professor in Statistics for Genomics – Responsible for OraMod data analysis and modeling
Telephone: +31(0)204442368
Fax: +31(0)736139388

VU University Medical Center is a leading health institution in the Netherlands for healthcare and research. The VUmc will participate with two departments: the Department of Otolaryngology – Head & Neck Surgery and the Department of Epidemiology & Biostatistics. The scientific research carried out at the VU University Medical Center is closely linked to issues that are important both for the hospital itself and for society in general. The aim of research is to expand knowledge (fundamental research) and to apply this knowledge to the health service (strategic and applied research).
The Department of Otolaryngology – Head & Neck Surgery chaired by Prof Leemans is one of the leading head and neck cancer services in the Netherlands treating annually >400 new patients. Prof Brakenhoff heads the section Tumour Biology within the Department that encompasses a laboratory with >20 researchers and all facilities for up to date molecular research. The Dept. focuses on translational research, and brought sentinel node biopsy and HPV testing to the clinic. There is a close interaction between clinicians and researchers. Research themes within the Department are: 1) the aetiology of head and neck cancer, 2) the identification of the genes causing head and neck cancer, 3) the role of HPV, 4) molecular diagnosis and staging, 5) field cancerization, 6) identification of novel therapeutic targets for personalized treatment, and 7) molecular imaging. The VUMC can count on the Microarray Core Facility (MAF) which is involved in a wide spectrum of (inter-) national cancer research and clinical genetics projects. The facilities’ expertise in processing clinical archival material (FFPE) for microarray CGH has a world-wide reputation.
The Section Biostatistics of the Department of Epidemiology & Biostatistics provides consultation for numerous epidemiological and clinical studies. Moreover, it focuses on methodological research on screening strategies and analysis of genomics data.

Role in OraMod: The VU Medical Center is one of the reference centres for the OraMod clinical study execution, and as such is responsible for the design of the clinical study and will be deeply involved in the clinical study execution and on the assessment of clinical impacts.
The VU University Department of Bio-statistics is responsible for prediction modelling in a general sense. Specifically: a) automated updating of predictive models; b) strategies and tools for integrating objective predictions with clinician’s knowledge; and c) comparing new prediction tools with existing ones.